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MECHANISM DILIGENCE · CELL READING GUIDE

Explore the cell without 3D

Read the 20 components in the existing animal-cell model. The reference cell is 30 µm across; dimensions, positions and motion include assumptions and placeholders. This is a teaching model, not a measurement of a particular cell.

Independent scientific review is pending. The component descriptions and source associations remain subject to review.

Boundaries

Plasma membrane

Selective exchange and surface signaling.

Size in the existing model
Cell diameter: 30 µm reference; membrane thickness unresolved
Movement and limits
Fixed boundary in this model.

Size evidence: The table lists a 30 micrometre cell diameter. It does not establish membrane thickness.

Context and source

NIGMS · organelle dimensions

Reference dimensions vary between cells and states.

This is the existing viewer's broad reference association, not a completed claim-by-claim review.

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Nuclear structures

Nucleus

Contains nuclear DNA and coordinates gene expression.

Size in the existing model
5 µm diameter reference
Movement and limits
Stationary reference compartment.

Size evidence: The table lists a 5 micrometre nucleus diameter as an average, not a universal value.

Context and source

NIGMS · organelle dimensions

Reference dimensions vary between cells and states.

This is the existing viewer's broad reference association, not a completed claim-by-claim review.

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Nuclear structures

Nucleolus

Ribosomal RNA production and ribosome assembly.

Size in the existing model
1 µm diameter assumption
Movement and limits
Stationary; assembly dynamics planned.
Context and source

Viana et al. · Nature (2023)

Human induced pluripotent stem cells; cellular organization varies with cell shape and state. Dataset not imported into this viewer.

This is the existing viewer's broad reference association, not a completed claim-by-claim review.

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Nuclear structures

Chromatin

DNA packaged with proteins; accessibility helps regulate gene expression.

Size in the existing model
Folded chromatin shown schematically
Movement and limits
Static organization; genomic modeling planned.
Context and source

Viana et al. · Nature (2023)

Human induced pluripotent stem cells; cellular organization varies with cell shape and state. Dataset not imported into this viewer.

This is the existing viewer's broad reference association, not a completed claim-by-claim review.

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Nuclear structures

Nuclear pore complex

Selective transport between nucleus and cytoplasm.

Size in the existing model
0.1 µm marker assumption
Movement and limits
Fixed in nuclear envelope; transport is not simulated.
Context and source

Viana et al. · Nature (2023)

Human induced pluripotent stem cells; cellular organization varies with cell shape and state. Dataset not imported into this viewer.

This is the existing viewer's broad reference association, not a completed claim-by-claim review.

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Membrane systems

Endoplasmic reticulum

Protein processing and lipid synthesis; continuous with the nuclear envelope.

Size in the existing model
Network extent and lumen width are schematic
Movement and limits
Fixed network; trafficking represented separately.
Context and source

Viana et al. · Nature (2023)

Human induced pluripotent stem cells; cellular organization varies with cell shape and state. Dataset not imported into this viewer.

This is the existing viewer's broad reference association, not a completed claim-by-claim review.

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Membrane systems

Golgi apparatus

Modifies and sorts proteins and lipids.

Size in the existing model
2 µm stack extent assumption
Movement and limits
Fixed stack; vesicle kinetics planned.
Context and source

Viana et al. · Nature (2023)

Human induced pluripotent stem cells; cellular organization varies with cell shape and state. Dataset not imported into this viewer.

This is the existing viewer's broad reference association, not a completed claim-by-claim review.

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Organelles

Mitochondrion

Oxidative phosphorylation and other metabolic functions.

Size in the existing model
1.5–2 µm length; 0.6 µm width assumptions
Movement and limits
Fixed instances; fusion, fission and remodeling planned.

Size evidence: The table gives typical lengths of 1–2 micrometres, with lengths up to 7 micrometres. Our narrower range and 0.6 micrometre width remain model assumptions.

Context and source

NIGMS · organelle dimensions

Reference dimensions vary between cells and states.

This is the existing viewer's broad reference association, not a completed claim-by-claim review.

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Organelles

Lysosome

Acidic degradation of delivered cellular material.

Size in the existing model
0.5 µm diameter assumption
Movement and limits
Fixed instances; acidification and turnover planned.

Size evidence: The table gives diameters of 50–3,000 nanometres. Our 0.5 micrometre sphere is an illustrative choice within that range, not a measured lysosome.

Context and source

NIGMS · organelle dimensions

Reference dimensions vary between cells and states.

This is the existing viewer's broad reference association, not a completed claim-by-claim review.

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Organelles

Peroxisome

Oxidative metabolism including fatty-acid processing.

Size in the existing model
0.4 µm diameter assumption
Movement and limits
Fixed instances; biochemical reactions planned.
Context and source

Viana et al. · Nature (2023)

Human induced pluripotent stem cells; cellular organization varies with cell shape and state. Dataset not imported into this viewer.

This is the existing viewer's broad reference association, not a completed claim-by-claim review.

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Organelles

Endosome

Sorts internalized material toward recycling or degradation.

Size in the existing model
0.6 µm diameter assumption
Movement and limits
Fixed instances; maturation and sorting planned.
Context and source

Viana et al. · Nature (2023)

Human induced pluripotent stem cells; cellular organization varies with cell shape and state. Dataset not imported into this viewer.

This is the existing viewer's broad reference association, not a completed claim-by-claim review.

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Molecular machinery

Ribosome

Translates messenger RNA into protein.

Size in the existing model
25 nm diameter reference
Movement and limits
Fixed representative instances; translation kinetics planned.

Size evidence: The table gives diameters of 20–30 nanometres. The model uses 25 nanometres as a representative value.

Context and source

NIGMS · organelle dimensions

Reference dimensions vary between cells and states.

This is the existing viewer's broad reference association, not a completed claim-by-claim review.

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Cytoskeleton

Microtubule

Intracellular transport tracks and structural organization.

Size in the existing model
25 nm width reference
Movement and limits
Static tracks; polymerization planned.

Size evidence: The NIGMS page does not establish this width. An indexed NCBI Bookshelf textbook excerpt describes an approximate 25 nanometre diameter. This is provisional reference support, not calibration of our model geometry or dynamics.

The Cell: Microtubules (NCBI Bookshelf)

Indexed chapter excerpt inspected; direct chapter access presented a browser challenge. Full chapter not inspected.

Context and source

NIGMS · organelle dimensions

Reference dimensions vary between cells and states.

This is the existing viewer's broad reference association, not a completed claim-by-claim review.

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Cytoskeleton

Actin filament

Cell shape, force generation and movement.

Size in the existing model
7 nm width reference
Movement and limits
Static fibers; force and turnover models planned.

Size evidence: The NIGMS page does not establish this width. An indexed NCBI Bookshelf textbook excerpt describes an approximate 7 nanometre diameter. This is provisional reference support, not calibration of our model geometry or dynamics.

The Cell: Structure and Organization of Actin Filaments (NCBI Bookshelf)

Indexed chapter excerpt inspected; direct chapter access presented a browser challenge. Full chapter not inspected.

Context and source

NIGMS · organelle dimensions

Reference dimensions vary between cells and states.

This is the existing viewer's broad reference association, not a completed claim-by-claim review.

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Tracked examples

Transport vesicle

Illustrates a membrane-bound cargo moving along a track.

Size in the existing model
0.1 µm diameter assumption
Movement and limits
Illustrative directed trajectory; no calibrated transport speed.
Context and source

Viana et al. · Nature (2023)

Human induced pluripotent stem cells; cellular organization varies with cell shape and state. Dataset not imported into this viewer.

This is the existing viewer's broad reference association, not a completed claim-by-claim review.

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Tracked examples

Soluble protein

Illustrates a soluble molecule exploring cytoplasmic space.

Size in the existing model
5 nm diameter placeholder
Movement and limits
Bounded illustrative motion, not calibrated Brownian dynamics.
Context and source

Viana et al. · Nature (2023)

Human induced pluripotent stem cells; cellular organization varies with cell shape and state. Dataset not imported into this viewer.

This is the existing viewer's broad reference association, not a completed claim-by-claim review.

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Tracked examples

Drug-sized probe

A generic visualization probe; no named drug or target affinity is modeled.

Size in the existing model
1 nm diameter placeholder
Movement and limits
Bounded illustrative trajectory; no permeability or exposure prediction.
Context and source

Viana et al. · Nature (2023)

Human induced pluripotent stem cells; cellular organization varies with cell shape and state. Dataset not imported into this viewer.

This is the existing viewer's broad reference association, not a completed claim-by-claim review.

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Molecular machinery

Membrane receptor

Represents a surface signaling protein.

Size in the existing model
10 nm extent placeholder
Movement and limits
Fixed in the boundary; binding and downstream signaling planned.
Context and source

Viana et al. · Nature (2023)

Human induced pluripotent stem cells; cellular organization varies with cell shape and state. Dataset not imported into this viewer.

This is the existing viewer's broad reference association, not a completed claim-by-claim review.

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Nuclear structures

Nuclear envelope

Separates nucleoplasm from cytoplasm and is continuous with the ER membrane system.

Size in the existing model
Two surface layers shown schematically; spacing not a calibrated envelope measurement
Movement and limits
Static envelope; transport through pores is not simulated.
Context and source

Viana et al. · Nature (2023)

Human induced pluripotent stem cells; cellular organization varies with cell shape and state. Dataset not imported into this viewer.

This is the existing viewer's broad reference association, not a completed claim-by-claim review.

Back to component index

Membrane systems

ER–mitochondria contact site

Represents apposed organelle membranes that support interorganelle communication without fusion.

Size in the existing model
20 nm illustrative gap at one selected interface
Movement and limits
Fixed illustrative contact; tether exchange and contact remodeling require data.
Context and source

Obara et al. · Nature (2024)

ER–mitochondria contact interfaces and VAPB dynamics; includes COS7 imaging. Geometry and trajectories here are original illustrations.

This is the existing viewer's broad reference association, not a completed claim-by-claim review.

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Check what the model can tell you

Optional reflection questions; no score or validated assessment is implied. Consider your answer before opening the explanation.

1. Does the model's 30 micrometre reference diameter mean every cell has that diameter?

Reveal explanation 1

No. It is the reference size chosen for this teaching model. It does not establish the size of an individual cell or a universal size across cell types and states.

Revisit the relevant component

2. Can the drug-sized probe's path tell you how quickly a real medicine enters a cell?

Reveal explanation 2

No. The probe has a placeholder size and an illustrative trajectory. The model supplies no named drug, membrane permeability or calibrated exposure prediction.

Revisit the relevant component

3. Is the displayed contact gap a reconstruction of the cited experiment?

Reveal explanation 3

No. The fixed gap is an illustration. The source study and our geometry are distinct; citing the paper does not turn the model's dimensions or motion into measured data.

Revisit the relevant component